APOPTOSIS AND DISEASE

被引：676

作者：

CARSON, DA

RIBEIRO, JM

机构：

[1] Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla

来源：

LANCET | 1993年 / 341卷 / 8855期

关键词：

D O I：

10.1016/0140-6736(93)91154-E

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The intercellular connections that characterise advanced forms of life would not be possible without a mechanism to remove individual cells that are no longer needed, or that function abnormally. Such physiological cell death, in the absence of inflammation, is achieved by apoptosis, a structurally distinct programmed cell death pathway. Defective regulation of programmed cell death may play a part in the aetiology of cancer, AIDS, autoimmune diseases, and degenerative diseases of the central nervous system. The pharmacological manipulation of apoptosis offers new possibilities for the prevention and treatment of these illnesses.

引用

页码：1251 / 1254

页数：4

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