Tyrosine Derivatives Isolated from Streptomyces sp IFM 10937 in a Screening Program for TRAIL-Resistance-Overcoming Activity

被引：32

作者：

Ahmed, Firoj ^{[1
]}

Ohtsuki, Takashi ^{[1
]}

Aida, Wataru ^{[1
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 11期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1021/np8004248

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Exploration of actinomycetes for isolation of natural products for abrogating TRAIL resistance led to the isolation of two new tyrosine derivatives (1 and 2) along with novobiocin (3). The structures of 1 and 2 were determined by spectroscopic methods, while the absolute configuration was determined by analyzing CD spectra and by a modified Marfey's method. Compounds 1 (150,mu M) and 3 (37.5 and 75 mu M) in combination with TRAIL showed synergistic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.

引用

页码：1963 / 1966

页数：4

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