Energy restriction controls aging through neuroendocrine signal transduction

被引:24
作者
Berner, YN
Stern, F
机构
[1] Hebrew Univ Jerusalem, Fac Agr Food & Environm Qual Sci, Inst Biochem Food Sci & Nutr, IL-76100 Rehovot, Israel
[2] Tel Aviv Univ, Sackler Sch Med, Meir Hosp, IL-69978 Tel Aviv, Israel
关键词
energy restriction; aging; neuroendocrine; signal transduction; lifespan;
D O I
10.1016/j.arr.2003.10.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Since the work of McCay in 1935, demonstrating the effect of energy restricted diet on the lifespan of rats, many studies have confirmed these findings in different species. Several mechanisms have been suggested, including among others, growth retardation, diminished apoptosis, decreased oxidative damage, altered glucose utilization, changes in gene expression, enhanced stress responsiveness and hormesis. There is some evidence that energy restriction (ER) exerts important metabolic effects on the aging process and longevity through intra- and intercellular signal transduction transmitters, with several signaling pathways mediating its beneficial action. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:189 / 198
页数:10
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