Association of heat shock proteins with all-cause mortality

被引：4

作者：

Broer, L. ^{[1
,2
]}

Demerath, E. W. ^{[3
]}

Garcia, M. E. ^{[4
]}

Homuth, G. ^{[5
]}

Kaplan, R. C. ^{[6
]}

Lunetta, K. L. ^{[7
,8
]}

Tanaka, T. ^{[9
]}

Tranah, G. J. ^{[10
]}

Walter, S. ^{[11
]}

Arnold, A. M. ^{[12
]}

Atzmon, G. ^{[13
,14
,15
,16
]}

Harris, T. B. ^{[4
]}

Hoffmann, W. ^{[17
]}

Karasik, D. ^{[8
,18
,19
]}

Kiel, D. P. ^{[8
,18
,19
]}

Kocher, T. ^{[20
]}

Launer, L. J. ^{[4
]}

Lohman, K. K. ^{[21
]}

Rotter, J. I. ^{[22
]}

Tiemeier, H. ^{[1
,2
,23
]}

Uitterlinden, A. G. ^{[1
,24
]}

Wallaschofski, H. ^{[25
]}

Bandinelli, S. ^{[26
]}

Doerr, M. ^{[27
]}

Ferrucci, L. ^{[9
]}

Franceschini, N. ^{[28
]}

Gudnason, V. ^{[29
,30
]}

Hofman, A. ^{[1
]}

Liu, Y. ^{[31
]}

Murabito, J. M. ^{[8
,32
]}

Newman, A. B. ^{[33
]}

Oostra, B. A. ^{[34
]}

Psaty, B. M. ^{[35
,36
,37
,38
]}

Smith, A. V. ^{[29
,30
]}

van Duijn, C. M. ^{[1
,2
]}

机构：

[1] Erasmus MC, Dept Epidemiol, NL-3000 CA Rotterdam, Netherlands

[2] Netherlands Consortium Hlth Aging, Rotterdam, Netherlands

[3] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[4] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA

[5] Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany

[6] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[7] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[8] NHLBI, Framingham Heart Study, Framingham, MA USA

[9] NIA, Clin Res Branch, Baltimore, MD 21224 USA

[10] Calif Pacific Med Ctr, San Francisco, CA USA

[11] Harvard Univ, Sch Publ Hlth, Dept Soc Human Dev & Hlth, Boston, MA 02115 USA

[12] Univ Washington, Dept Biostat, Seattle, WA 98195 USA

[13] Albert Einstein Coll Med, Inst Aging Res, Bronx, NY 10467 USA

[14] Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10467 USA

[15] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[16] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA

[17] Ernst Moritz Arndt Univ Greifswald, Inst Community Med, Greifswald, Germany

[18] Hebrew Senior Life Inst Aging Res, Boston, MA USA

[19] Harvard Univ, Sch Med, Boston, MA USA

[20] Ernst Moritz Arndt Univ Greifswald, Sch Dent, Greifswald, Germany

[21] Wake Forest Univ, Bowman Gray Sch Med, Sticht Ctr Aging, Winston Salem, NC USA

[22] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

[23] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands

[24] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[25] Ernst Moritz Arndt Univ Greifswald, Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany

[26] ASF, Geriatr Unit, Florence, Italy

[27] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[28] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA

[29] Iceland Heart Assoc, Kopavogur, Iceland

[30] Univ Iceland, Reykjavik, Iceland

[31] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[32] Boston Univ, Sch Med, Gen Internal Med Sect, Dept Med, Boston, MA 02118 USA

[33] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA

[34] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

[35] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[36] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[37] Univ Washington, Dept Hlth Serv, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA

[38] Grp Hlth Cooperat Puget Sound, Grp Hlth Res Unit, Seattle, WA USA

来源：

AGE | 2013年 / 35卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Heat shock proteins; HEAT shock factor 2; All-cause mortality; LIFE-SPAN EXTENSION; CAENORHABDITIS-ELEGANS; STRESS-RESPONSE; LONGEVITY; GENE; HORMESIS; RESISTANCE; EXTENDS; HSP22; AGE;

D O I：

10.1007/s11357-012-9417-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Experimental mild heat shock is widely known as an intervention that results in extended longevity in various models along the evolutionary lineage. Heat shock proteins (HSPs) are highly upregulated immediately after a heat shock. The elevation in HSP levels was shown to inhibit stress-mediated cell death, and recent experiments indicate a highly versatile role for these proteins as inhibitors of programmed cell death. In this study, we examined common genetic variations in 31 genes encoding all members of the HSP70, small HSP, and heat shock factor (HSF) families for their association with all-cause mortality. Our discovery cohort was the Rotterdam study (RS1) containing 5,974 participants aged 55 years and older (3,174 deaths). We assessed 4,430 single nucleotide polymorphisms (SNPs) using the HumanHap550K Genotyping BeadChip from Illumina. After adjusting for multiple testing by permutation analysis, three SNPs showed evidence for association with all-cause mortality in RS1. These findings were followed in eight independent population-based cohorts, leading to a total of 25,007 participants (8,444 deaths). In the replication phase, only HSF2 (rs1416733) remained significantly associated with all-cause mortality. Rs1416733 is a known cis-eQTL for HSF2. Our findings suggest a role of HSF2 in all-cause mortality.

引用

页码：1367 / 1376

页数：10

共 39 条

[1]

Heat shock factors: integrators of cell stress, development and lifespan [J].

Akerfelt, Malin ;

Morimoto, Richard I. ;

Sistonen, Lea .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2010, 11 (08) :545-555

[2]

The allele (A)-110 in the promoter region of the HSP70-1 gene is unfavorable to longevity in women [J].

Altomare, K ;

Greco, V ;

Bellizzi, D ;

Berardelli, M ;

Dato, S ;

DeRango, F ;

Garasto, S ;

Rose, G ;

Feraco, E ;

Mari, V ;

Passarino, G ;

Franceschi, C ;

De Benedictis, G .

BIOGERONTOLOGY, 2003, 4 (04) :215-220

[3]

ProbABEL package for genome-wide association analysis of imputed data [J].

Aulchenko, Yurii S. ;

Struchalin, Maksim V. ;

van Duijn, Cornelia M. .

BMC BIOINFORMATICS, 2010, 11

[4]

CHURCHILL GA, 1994, GENETICS, V138, P963

[5]

Hormesis extends the correlation between stress resistance and life span in long-lived mutants of Caenorhabditis elegans [J].

Cypser, J ;

Johnson, TE .

HUMAN & EXPERIMENTAL TOXICOLOGY, 2001, 20 (06) :295-296

[6]

Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity [J].

Cypser, JR ;

Johnson, TE .

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2002, 57 (03) :B109-B114

[7]

Fisher R, 1935, DESIGN EXPT, V3

[8]

Garigan D, 2002, GENETICS, V161, P1101

[9]

Heat shock proteins 27 and 70 [J].

Garrido, Carmen ;

Brunet, Mathilde ;

Didelot, Celine ;

Zermati, Yael ;

Schmitt, Elise ;

Kroemer, Guido .

CELL CYCLE, 2006, 5 (22) :2592-2601

[10]

Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress [J].

Hercus, MJ ;

Loeschcke, V ;

Rattan, SIS .

BIOGERONTOLOGY, 2003, 4 (03) :149-156

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