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Univ Tras Os Montes & Alto Douro, Ctr Genom & Biotechnol CGB, Inst Biotechnol & Bioengn IBB, P-5001801 Vila Real, Portugal Univ Tras Os Montes & Alto Douro, Ctr Genom & Biotechnol CGB, Inst Biotechnol & Bioengn IBB, P-5001801 Vila Real, Portugal