Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning

被引：264

作者：

Kwong, Peter D. ^{[1
]}

Mascola, John R. ^{[1
]}

Nabel, Gary J. ^{[1
]}

机构：

[1] NIAID, Vaccine Res Ctr, US Natl Inst Hlth, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2013年 / 13卷 / 09期

基金：

美国国家卫生研究院;

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; HUMAN MONOCLONAL-ANTIBODIES; CROSS-CLADE NEUTRALIZATION; MUCOSAL SHIV CHALLENGE; B-CELL RESPONSES; STRUCTURAL BASIS; POTENT NEUTRALIZATION; ENVELOPE GLYCOPROTEIN; CRYSTAL-STRUCTURE; CD4-BINDING SITE;

D O I：

10.1038/nri3516

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The field of HIV-1 vaccine research has seen a renaissance with the identification of antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural mode of target recognition that these antibodies use and the immune pathways that lead to their development is emerging. This knowledge has provided fundamental insights into the pathways that elicit broadly neutralizing antibodies and provides a foundation for active and passive immunization strategies to prevent HIV-1 infection.

引用

页码：693 / 701

页数：9

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