Evolution of enzymatic activities in the enolase superfamily:: Identification of a "new" general acid catalyst in the active site of D-galactonate dehydratase from Escherichia coli

被引:34
作者
Wieczorek, SJ
Kalivoda, KA
Clifton, JG
Ringe, D
Petsko, GA
Gerlt, JA [1 ]
机构
[1] Univ Illinois, Dept Biochem, Urbana, IL 61801 USA
[2] Brandeis Univ, Rosenstiel Basic Med Sci Res Ctr, Grad Dept Biochem, Waltham, MA 02154 USA
关键词
D O I
10.1021/ja990500w
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:4540 / 4541
页数:2
相关论文
共 11 条
[11]   Importance of mechanistic imperatives in enzyme-catalyzed beta-elimination reactions: Stereochemical consequences of the dehydration reactions catalyzed by D-galactonate dehydratase from Escherichia coli and D-glucarate dehydratase from Pseudomonas putida [J].
Palmer, DRJ ;
Wieczorek, SJ ;
Hubbard, BK ;
Mrachko, GT ;
Gerlt, JA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (40) :9580-9581