Colonic absorption of antiepileptic agents

被引:18
作者
Stevenson, CM
Kim, JS
Fleisher, D
机构
[1] UNIV MICHIGAN,COLL PHARM,DEPT PHARMACEUT,ANN ARBOR,MI 48109
[2] THERAPEUT SYST RES LABS,ANN ARBOR,MI
[3] WHITEHALL ROBINS HLTH CARE,HAMMONTON,NJ
关键词
gabapentin; phenytoin; toxicity; colonic absorption;
D O I
10.1111/j.1528-1157.1997.tb01078.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Purpose: To evaluate a canine intestinal access-port model to study colonic absorption of drugs. The antiepileptic drugs phenytoin and gabapentin were chosen to study absorption of a lipophilic and hydrophilic compound, respectively. Methods: Drug plasma level-time plots were generated subsequent to small intestinal and colonic drug administration of both drugs. The poorly water-soluble phenytoin was administered in two doses to evaluate the impact of dissolution rate limits on colonic absorption. Maximal plasma concentration (C-max) and area under the plasma level-time curve (AUG) were used to assess the relative contribution of colonic absorption to plasma levels. Results: Whereas colonic gabapentin AUC and C-max were only 0.25 and 0.15 of those seen after small intestinal administration, colonic phenytoin AUC and C-max were one half and equivalent to, respectively, those observed for small intestinal administration. Furthermore, colonic administration of a higher phenytoin dose showed secondary maxima and continued increases in drug plasma levels with time. Conclusions: Colonic gabapentin absorption is poor compared with upper intestinal absorption, consistent with membrane transport rate limits to the absorption of this hydrophilic AED. Peak phenytoin plasma levels from colonic and small intestinal administration are comparable, indicating membrane transport does not limit absorption of this lipophilic agent. Continued plasma-level increases from higher phenytoin doses are consistent with dissolution-rate control of drug absorption in the colon. We suggest that colonic absorption provides a greater potential for toxicity from phenytoin overdose as a function of continued drug dissolution than for gabapentin overdose.
引用
收藏
页码:63 / 67
页数:5
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