(+)-α-viniferin, a stilbene Trimer from Caragana chamlague inhibits acetylcholinesterase

被引：52

作者：

Sung, SH

Kang, SY

Lee, KY

Park, MJ

Kim, JH

Park, JH

Kim, YC ^{[1
]}

Kim, J

Kim, YC ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2002年 / 25卷 / 01期

关键词：

Caragana chamlague; Leguminosae; AChE inhibitors; (+)-alpha-viniferin; kobophenol A;

D O I：

10.1248/bpb.25.125

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract resulted in the isolation and identification of two active stilbene oligomers, (+)-alpha -viniferin (1) and kobophenol A (2). Both 1 and 2 inhibited AChE activity in a dose-dependent manner, and the IC50 values of I and 2 were 2.0 and 115.8 mum, respectively. The AChE inhibitory activity of I was specific, reversible and noncompetitive.

引用

页码：125 / 127

页数：3