Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cells

被引：78

作者：

Deng, Junhao ^{[1
]}

Zhang, Yiling ^{[1
]}

Xie, Yong ^{[1
]}

Zhang, Licheng ^{[1
]}

Tang, Peifu ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, 28 Fuxin Rd, Beijing 100853, Peoples R China

来源：

STEM CELLS INTERNATIONAL | 2018年 / 2018卷

基金：

中国国家自然科学基金;

关键词：

HIGH-DOSE METHYLPREDNISOLONE; FUNCTIONAL RECOVERY; PROGENITOR CELLS; SAFETY; MOUSE; GENERATION; MODEL; TRIAL; FAIL;

D O I：

10.1155/2018/5653787

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Spinal cord injury (SCI) is an intractable and worldwide difficult medical challenge with limited treatments. Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well. Thus, the implementation of induced pluripotent stem cells (iPSCs), which can be generated from adult somatic cells and differentiated into NS/PCs, provides an effective alternation in the treatment of SCI. However, as researches further deepen, there is accumulating evidence that the use of iPSC-derived NS/PCs shows mounting concerns of safety, especially the tumorigenicity. This review discusses the tumorigenicity of iPSC-derived NS/PCs focusing on the two different routes of tumorigenicity (teratomas and true tumors) and underlying mechanisms behind them, as well as possible solutions to circumvent them.

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