The tumorigenicity of human embryonic and induced pluripotent stem cells

被引：651

作者：

Ben-David, Uri ^{[1
]}

Benvenisty, Nissim ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Genet, Stem Cell Unit, Alexander Silberman Inst Life Sci, IL-91904 Jerusalem, Israel

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 04期

基金：

以色列科学基金会;

关键词：

GENE-EXPRESSION; TERATOMA FORMATION; COPY NUMBER; CYTOTOXIC ANTIBODY; HUMAN FIBROBLASTS; CANCER; GENERATION; MYC; MOUSE; CULTURE;

D O I：

10.1038/nrc3034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The unique abilities of human pluripotent stem cells to self-renew and to differentiate into cells of the three germ layers make them an invaluable tool for the future of regenerative medicine. However, the same properties also make them tumorigenic, and therefore hinder their clinical application. Hence, the tumorigenicity of human embryonic stem cells (HESCs) has been extensively studied. Until recently, it was assumed that human induced pluripotent stem cells (HiPSCs) would behave like their embryonic counterparts in respect to their tumorigenicity. However, a rapidly accumulating body of evidence suggests that there are important genetic and epigenetic differences between these two cell types, which seem to influence their tumorigenicity.

引用

页码：268 / 277

页数：10

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