The tumorigenicity of human embryonic and induced pluripotent stem cells

被引：651

作者：

Ben-David, Uri ^{[1
]}

Benvenisty, Nissim ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Genet, Stem Cell Unit, Alexander Silberman Inst Life Sci, IL-91904 Jerusalem, Israel

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 04期

基金：

以色列科学基金会;

关键词：

GENE-EXPRESSION; TERATOMA FORMATION; COPY NUMBER; CYTOTOXIC ANTIBODY; HUMAN FIBROBLASTS; CANCER; GENERATION; MYC; MOUSE; CULTURE;

D O I：

10.1038/nrc3034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The unique abilities of human pluripotent stem cells to self-renew and to differentiate into cells of the three germ layers make them an invaluable tool for the future of regenerative medicine. However, the same properties also make them tumorigenic, and therefore hinder their clinical application. Hence, the tumorigenicity of human embryonic stem cells (HESCs) has been extensively studied. Until recently, it was assumed that human induced pluripotent stem cells (HiPSCs) would behave like their embryonic counterparts in respect to their tumorigenicity. However, a rapidly accumulating body of evidence suggests that there are important genetic and epigenetic differences between these two cell types, which seem to influence their tumorigenicity.

引用

页码：268 / 277

页数：10

共 129 条

[21] Signaling pathways in cancer and embryonic stem cells [J].

Dreesen, Oliver ;

Brivanlou, Ali H. .

STEM CELL REVIEWS, 2007, 3 (01) :7-17

[22] Rem2 GTPase maintains survival of human embryonic stem cells as well as enhancing reprogramming by regulating p53 and cyclin D1 [J].

Edel, Michael J. ;

Menchon, Cristina ;

Menendez, Sergio ;

Consiglio, Antonella ;

Raya, Angel ;

Izpisua Belmonte, Juan Carlos .

GENES & DEVELOPMENT, 2010, 24 (06) :561-573

[23] Establishment of human embryonic stem cell-transfected clones carrying a marker for undifferentiated cells [J].

Eiges, R ;

Schuldiner, M ;

Drukker, M ;

Yanuka, O ;

Itskovitz-Eldor, J ;

Benvenisty, N .

CURRENT BIOLOGY, 2001, 11 (07) :514-518

[24] Myc's broad reach [J].

Eilers, Martin ;

Eisenman, Robert N. .

GENES & DEVELOPMENT, 2008, 22 (20) :2755-2766

[25] Roles of Kruppel-like factor 4 in normal homeostasis, cancer and stem cells [J].

Evans, Paul M. ;

Liu, Chunming .

ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2008, 40 (07) :554-564

[26] Separation of SSEA-4 and TRA-1-60 Labelled Undifferentiated Human Embryonic Stem Cells from A Heterogeneous Cell Population Using Magnetic-Activated Cell Sorting (MACS) and Fluorescence-Activated Cell Sorting (FACS) [J].

Fong, Chui Yee ;

Peh, Gary S. L. ;

Gauthaman, Kalamegam ;

Bongso, Ariff .

STEM CELL REVIEWS AND REPORTS, 2009, 5 (01) :72-80

[27] The effects of culture on genomic imprinting profiles in human embryonic and fetal mesenchymal stem cells [J].

Frost, Jennifer M. ;

Monk, Dave ;

Moschidou, Dafni ;

Guillot, Pascale V. ;

Stanier, Philip ;

Minger, Stephen L. ;

Fisk, Nicholas M. ;

Moore, Harry D. ;

Moore, Gudrun E. .

EPIGENETICS, 2011, 6 (01) :52-62

[28] Trisomy 12 in HESC leads to no selective in vivo growth advantage in teratomas, but induces an increased abundance of renal development [J].

Gertow, Karin ;

Cedervall, Jessica ;

Unger, Christian ;

Szoke, Krisztina ;

Blennow, Elisabeth ;

Imreh, Marta P. ;

Ahrlund-Richter, Lars .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2007, 100 (06) :1518-1525

[29] Persistent Donor Cell Gene Expression among Human Induced Pluripotent Stem Cells Contributes to Differences with Human Embryonic Stem Cells [J].

Ghosh, Zhumur ;

Wilson, Kitchener D. ;

Wu, Yi ;

Hu, Shijun ;

Quertermous, Thomas ;

Wu, Joseph C. .

PLOS ONE, 2010, 5 (02)

[30] Reprogramming the Pluripotent Cell Cycle: Restoration of an Abbreviated G1 Phase in Human Induced Pluripotent Stem (iPS) Cells [J].

Ghule, Prachi N. ;

Medina, Ricardo ;

Lengner, Christopher J. ;

Mandeville, Matthew ;

Qiao, Meng ;

Dominski, Zbigniew ;

Lian, Jane B. ;

Stein, Janet L. ;

Van Wijnen, Andre J. ;

Stein, Gary S. .

JOURNAL OF CELLULAR PHYSIOLOGY, 2011, 226 (05) :1149-1156

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