Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins

被引:47
作者
Wan, Sheng Biao
Dou, Q. Ping
Chan, Tak Hang [1 ]
机构
[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Dept Appl Biol, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, State Key Lab Chinese Med & Mol Pharmacol, Kowloon, Hong Kong, Peoples R China
[3] Wayne State Univ, Sch Med, Barbara Ann Karmanos Canc Inst, Prevent Program, Detroit, MI 48202 USA
[4] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48202 USA
关键词
D O I
10.1016/j.tet.2006.04.010
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The regiospecific and enantioselective syntheses of various methylated regioisomers of epicatechin gallate (EGC) and epigallocatechin gallate (EGCG) have been achieved. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5897 / 5904
页数:8
相关论文
共 24 条
[21]   Docking studies and model development of tea polyphenol proteasome inhibitors: Applications to rational drug design [J].
Smith, DM ;
Daniel, KG ;
Wang, ZG ;
Guida, WC ;
Chan, TH ;
Dou, QP .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2004, 54 (01) :58-70
[22]   Identification of a methylated tea catechin as an inhibitor of degranulation in human basophilic KU812 cells [J].
Tachibana, H ;
Sunada, Y ;
Miyase, T ;
Sano, M ;
Maeda-Yamamoto, M ;
Yamada, K .
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2000, 64 (02) :452-454
[23]   Studies in polyphenol chemistry and bioactivity.: 1.: Preparation of building blocks from (+)-catechin.: Procyanidin formation.: Synthesis of the cancer cell growth inhibitor, 3-O-galloyl-(2R,3R)-epicatechin-4β,8-[3-O-galloyl-(2R,3R)-epicatechin] [J].
Tückmantel, W ;
Kozikowski, AP ;
Romanczyk, LJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (51) :12073-12081
[24]  
Wu AH, 2003, CANCER RES, V63, P7526