Amine-boranes:: effective reducing agents for the deracemisation of DL-amino acids using L-amino acid oxidase from Proteus myxofaciens

被引：88

作者：

Alexandre, FR

Pantaleone, DP

Taylor, PP

Fotheringham, IG

Ager, DJ

Turner, NJ

机构：

[1] Univ Edinburgh, Dept Chem, Ctr Prot Technol, Edinburgh EH9 3JJ, Midlothian, Scotland

[2] Great Lakes Fine Chem, Mt Prospect, IL 60056 USA

[3] MediChem Res Inc, Woodridge, IL 60517 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 04期

关键词：

amine borane; D-amino acid; L-amino acid oxidase; deracemisation;

D O I：

10.1016/S0040-4039(01)02233-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The deracemisation of DL-alpha-aluino acids using L-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of D-amino acids were obtained in yields of up to 90%, and e.c. >99%. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：707 / 710

页数：4

共 19 条

[1]

[Anonymous], ORG PREP PROCED INT

[2]

BEARD TM, 2001, IN PRESS CHEM COMMUN

[3] CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT [J].