Remarkable endo selectivity on hydroxylation of bicyclic lactam enolates with MoOPD and MoOPH

被引：21

作者：

Hara, O ^{[1
]}

Takizawa, J ^{[1
]}

Yamatake, T ^{[1
]}

Makino, K ^{[1
]}

Hamada, Y ^{[1
]}

机构：

[1] Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 44期

关键词：

hydroxylation; MoOPD; MoOPH; bicyclic lactam; endo selectivity;

D O I：

10.1016/S0040-4039(99)01616-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Remarkable endo selectivity was observed during the hydroxylation of the enolates derived from the bicyclic lactam 1a and its relatives with molybdenum oxidizing reagents, MoOPD and MoOPH, showing that the molybdenum reagents approach the enolate from the sterically hindered concave face of the lactam in spite of their bulkiness. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7787 / 7790

页数：4

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