New chiral phosphorus catalysts derived from (S)-binaphthol for highly enantioselective reduction of acetophenone by borane

被引：24

作者：

Ma, MFP

Li, KY

Zhou, ZG

Tang, CC ^{[1
]}

Chan, ASC

机构：

[1] Nankai Univ, State Key Lab Elemntoorgan Chem, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 17期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(99)00323-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New chiral (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine 1 and its borane complex 3 were prepared from (S)-binaphthol and their use as catalysts in enantioselective borane reductions of prochiral acetophenone were investigated. Enantiomeric excesses of up to 98.5% have been obtained using 6 mol% of 1 at room temperature and using 6 mol% of 3 at 100 degrees C. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：3259 / 3261

页数：3

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