Analysis of integrated virological and epidemiological reports of norovirus outbreaks collected within the Foodborne Viruses in Europe Network from 1 July 2001 to 30 June 2006

被引：167

作者：

Kroneman, A. ^{[1
]}

Verhoef, L. ^{[1
]}

Harris, J. ^{[2
]}

Vennema, H. ^{[1
]}

Duizer, E. ^{[1
]}

van Duynhoven, Y. ^{[1
]}

Gray, J. ^{[2
]}

Iturriza, M. ^{[2
]}

Boettiger, B. ^{[3
]}

Falkenhorst, G. ^{[3
]}

Johnsen, C. ^{[3
]}

von Bonsdorff, C. -H. ^{[4
]}

Maunula, L. ^{[4
]}

Kuusi, M. ^{[5
]}

Pothier, P. ^{[6
]}

Gallay, A. ^{[7
]}

Schreier, E. ^{[8
]}

Hohne, M. ^{[8
]}

Koch, J. ^{[8
]}

Szucs, G. ^{[9
]}

Reuter, G. ^{[9
]}

Krisztalovics, K. ^{[10
]}

Lynch, M. ^{[11
]}

McKeown, P. ^{[12
]}

Foley, B. ^{[12
]}

Coughlan, S. ^{[13
]}

Ruggeri, F. M. ^{[14
]}

Di Bartolo, I. ^{[14
]}

Vainio, K. ^{[15
]}

Isakbaeva, E. ^{[15
]}

Poljsak-Prijatelj, M. ^{[16
]}

Grom, A. Hocevar ^{[17
]}

Mijovski, J. Zimsek ^{[17
]}

Bosch, A. ^{[18
]}

Buesa, J. ^{[19
]}

Fauquier, A. Sanchez ^{[20
]}

Hernandez-Pezzi, G. ^{[20
]}

Hedlund, K. -O. ^{[21
]}

Koopmans, M. ^{[1
]}

机构：

[1] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, NL-3720 BA Bilthoven, Netherlands

[2] Hlth Protect Agcy, Ctr Infect, London, England

[3] State Serum Inst, Copenhagen, Denmark

[4] Univ Helsinki, Helsinki, Finland

[5] Natl Publ Hlth Inst, Helsinki, Finland

[6] Univ Dijon, F-21004 Dijon, France

[7] Inst Veille Sanit, St Maurice, France

[8] Robert Koch Inst, D-1000 Berlin, Germany

[9] Reg Inst State Publ Hlth Serv, Pecs, Hungary

[10] Natl Ctr Epidemiol, Budapest, Hungary

[11] Mater Misericordiae Univ Hosp, Dublin 7, Ireland

[12] Hlth Protect Surveillance Ctr, Dublin, Ireland

[13] Natl Virus Reference Lab, Dublin, Ireland

[14] Inst Super Sanita, Rome, Italy

[15] Norwegian Inst Publ Hlth, Oslo, Norway

[16] Univ Ljubljana, Ljubljana, Slovenia

[17] Inst Publ Hlth Republ Slovenia, Ljubljana, Slovenia

[18] Univ Barcelona, Barcelona, Spain

[19] Univ Valencia, Valencia, Spain

[20] Inst Salud Carlos III, Madrid, Spain

[21] Swedish Inst Infect Dis Control, Solna, Sweden

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 09期

关键词：

D O I：

10.1128/JCM.00499-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Foodborne Viruses in Europe network has developed integrated epidemiological and virological outbreak reporting with aggregation and sharing of data through a joint database. We analyzed data from reported outbreaks of norovirus (NoV)-caused gastroenteritis from 13 European countries (July 2001 to July 2006) for trends in time and indications of different epidemiology of genotypes and variants. Of the 13 countries participating in this surveillance network, 11 were capable of collecting integrated epidemiological and virological surveillance data and 10 countries reported outbreaks throughout the entire period. Large differences in the numbers and rates of reported outbreaks per country were observed, reflecting the differences in the focus and coverage of national surveillance systems. GII.4 strains predominated throughout the 5-year surveillance period, but the proportion of outbreaks associated with GII.4 rose remarkably during years in which NoV activity was particularly high. Spring and summer peaks indicated the emergence of genetically distinct variants within GII.4 across Europe and were followed by increased NoV activity during the 2002 - 2003 and 2004 - 2005 winter seasons. GII.4 viruses predominated in health care settings and in person-to-person transmission. The consecutive emergence of new GII.4 variants is highly indicative of immune-driven selection. Their predominance in health care settings suggests properties that facilitate transmission in settings with a high concentration of people such as higher virus loads in excreta or a higher incidence of vomiting. Understanding the mechanisms driving the changes in epidemiology and clinical impact of these rapidly evolving RNA viruses is essential to design effective intervention and prevention measures.

引用

页码：2959 / 2965

页数：7

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