The KEOPS complex: A Rosetta stone for telomere regulation?

被引：6

作者：

Bianchi, A

Shore, D

机构：

[1] Univ Geneva, Dept Biol Mol, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, NCCR Program Frontiers Genet, CH-1211 Geneva 4, Switzerland

来源：

CELL | 2006年 / 124卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The detailed mechanisms underlying telomere capping and its relationship to telomerase activity are still unclear, although many proteins have been implicated in either or both processes. In this issue of Cell, Downey et al. (2006) present the surprising identification of a new complex, called KEOPS, which promotes both telomere uncapping and elongation.

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页码：1125 / 1128

页数：4

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