A call for transparent reporting to optimize the predictive value of preclinical research

被引：873

作者：

Landis, Story C. ^{[1
]}

Amara, Susan G. ^{[2
]}

Asadullah, Khusru ^{[3
]}

Austin, Chris P. ^{[4
]}

Blumenstein, Robi ^{[5
]}

Bradley, Eileen W. ^{[6
]}

Crystal, Ronald G. ^{[7
]}

Darnell, Robert B. ^{[8
]}

Ferrante, Robert J. ^{[9
]}

Fillit, Howard ^{[10
]}

Finkelstein, Robert ^{[1
]}

Fisher, Marc ^{[11
]}

Gendelman, Howard E. ^{[12
]}

Golub, Robert M. ^{[13
]}

Goudreau, John L. ^{[14
]}

Gross, Robert A. ^{[15
]}

Gubitz, Amelie K. ^{[1
]}

Hesterlee, Sharon E. ^{[16
]}

Howells, David W. ^{[17
]}

Huguenard, John ^{[18
]}

Kelner, Katrina ^{[19
]}

Koroshetz, Walter ^{[1
]}

Krainc, Dimitri ^{[20
]}

Lazic, Stanley E. ^{[21
]}

Levine, Michael S. ^{[22
]}

Macleod, Malcolm R. ^{[23
]}

McCall, John M. ^{[25
]}

Moxley, Richard T., III ^{[24
]}

Narasimhan, Kalyani ^{[26
]}

Noble, Linda J. ^{[27
]}

Perrin, Steve ^{[28
]}

Porter, John D. ^{[1
]}

Steward, Oswald ^{[29
]}

Unger, Ellis ^{[30
]}

Utz, Ursula ^{[1
]}

Silberberg, Shai D. ^{[1
]}

机构：

[1] Natl Inst Neurol Disorders & Stroke, NIH, Bethesda, MD 20892 USA

[2] Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15213 USA

[3] Bayer HealthCare, D-13342 Berlin, Germany

[4] NIH, Natl Ctr Adv Translat Sci, Rockville, MD 20854 USA

[5] CHDI Management CHDI Fdn, New York, NY 10001 USA

[6] NIH, Ctr Review, Bethesda, MD 20892 USA

[7] Weill Cornell Med Coll, Dept Genet Med, New York, NY 10021 USA

[8] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10065 USA

[9] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15213 USA

[10] Alzheimers Drug Discovery Fdn, New York, NY 10019 USA

[11] Univ Massachusetts, Sch Med, Dept Neurol, Worcester, MA 01545 USA

[12] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68198 USA

[13] JAMA, Chicago, IL 60654 USA

[14] Michigan State Univ, Dept Neurol, E Lansing, MI 48824 USA

[15] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14642 USA

[16] Parent Project Muscular Dystrophy, Hackensack, NJ 07601 USA

[17] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Heidelberg, Vic 3081, Australia

[18] Stanford Univ, Stanford, CA 94305 USA

[19] AAAS, Washington, DC USA

[20] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[21] F Hoffmann La Roche & Co Ltd, CH-4070 Basel, Switzerland

[22] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[23] Univ Edinburgh, Western Gen Hosp, Dept Clin Neurosci, Edinburgh EH4 2XU, Midlothian, Scotland

[24] Univ Rochester, Med Ctr, Sch Med & Dent, Rochester, NY 14642 USA

[25] PharMac LLC, Boca Grande, FL 33921 USA

[26] Nat Neurosci, New York, NY 10013 USA

[27] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94143 USA

[28] ALS Therapy Dev Inst, Cambridge, MA 02139 USA

[29] Univ Calif Irvine, Reeve Irvine Res Ctr, Irvine, CA 92697 USA

[30] US FDA, Off New Drugs, Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA

来源：

NATURE | 2012年 / 490卷 / 7419期

关键词：

RANDOMIZED CONTROLLED-TRIALS; EMPIRICAL-EVIDENCE; STATISTICAL-ANALYSIS; CLINICAL-TRIALS; ANIMAL RESEARCH; QUALITY; DESIGN; EFFICACY; BIAS; PUBLICATION;

D O I：

10.1038/nature11556

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

引用

页码：187 / 191

页数：5

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