Mitochondria: Signaling with phosphatidic acid

被引：32

作者：

Yang, Chia-Ying

Frohman, Michael A. ^{[1
]}

机构：

[1] SUNY Stony Brook, Mol & Cellular Biol Grad Program, Stony Brook, NY 11794 USA

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2012年 / 44卷 / 08期

关键词：

Mitochondria; Phosphatidic acid; MitoPLD; Lipid signaling; Spermatogenesis; PHOSPHOLIPASE-D; NUAGE FORMATION; FUSION; PROTEIN; DYNAMICS; FISSION; DIACYLGLYCEROL; GERMLINE; SPERMATOGENESIS; LOCALIZATION;

D O I：

10.1016/j.biocel.2012.05.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria, once viewed as functioning relatively autonomously in the cell, have increasingly been recognized to be involved in numerous signaling networks that impact on a wide range of cell biological processes. In addition to the many types of proteins that mediate these pathways, the importance of signaling functions regulated via lipids and lipid second messengers generated on the mitochondrial surface is also becoming well appreciated. We focus here on phosphatidic acid, a lipid second messenger produced via several different pathways that can in turn stimulate the formation of multiple other bioactive lipids. Taken together, fascinating roles for phosphatidic acid and the connected lipids in mitochondrial function and interaction with other organelles are being uncovered. These pathways present new opportunities for the development of therapeutic approaches relevant to reproduction, metabolism, and neurodegenerative disease. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1346 / 1350

页数：5

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