Modern developments in molecular replacement

被引：18

作者：

Turkenburg, JP

Dodson, EJ

机构：

[1] Chemistry Department, University of York, Heslington

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(96)80025-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular replacement is a possible route to obtaining initial phasing for an unknown structure from a known, structurally related molecule. Recent years have seen an explosive growth in the number of protein structures solved using this technique. Automated packages can make the application quite straightforward. Progress has been made in the placing of fragments of complexes, and in the use of imprecise models from NMR or homology modelling. Such models have necessitated the development of new approaches to rebuilding and refinement.

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收藏

页码：604 / 610

页数：7

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