A practical asymmetric synthesis of 2,6-cis-disubstituted piperidines

被引：41

作者：

Ciblat, S

Besse, P

Canet, JL

Troin, Y

Veschambre, H

Gelas, J

机构：

[1] Univ Blaise Pascal, Ecole Natl Super Chim Clermont Ferrand, Lab Chim Heterocycles & Glucides, EA 987, F-63174 Aubiere, France

[2] Univ Blaise Pascal, Lab Synth Electrosynth & Etud Syst Interet Biol, CNRS, UMR 6504, F-63177 Aubiere, France

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(99)00226-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A highly diastereoselective intramolecular Mannich reaction involving enantiopure alpha-methylamine 7 and achiral aldehydes is employed to prepare enantiomerically pure 2,6-cis-disubstituted piperidines. This methodology provides an efficient and selective route to 2,6-cis-disubstituted piperidines, 2,6-cis-disubstituted 4-piperidones and 2,6-cis-disubstituted 4-piperidinols. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2225 / 2235

页数：11

共 20 条

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