Novel-object place conditioning: behavioral and dopaminergic processes in expression of novelty reward

被引:86
作者
Bevins, RA [1 ]
Besheer, J [1 ]
Palmatier, MI [1 ]
Jensen, HC [1 ]
Pickett, KS [1 ]
Eurek, S [1 ]
机构
[1] Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
关键词
cocaine; dopamine; drug abuse; eticlopride; locomotor activity; novelty seeking; Pavlovian conditioning; SCH-23390;
D O I
10.1016/S0166-4328(01)00326-6
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
In a choice situation, rats given repeated access to novel objects in one of two distinct environments display an increase in preference for the novelty-paired environment. The experiments in this present report extend the generality of this effect to new procedures. Further, this shift in preference depends on object novelty; no systematic shift in preference was observed if the environment was paired with a familiar object. Experiments in the present report also provided evidence against non-associative accounts that rely on mechanisms that leave the paired environment more novel than the unpaired environment (e.g. object interaction interfering with environmental familiarization). Consistent with a conditioning account is the loss of place conditioning when access time with the novel objects was shortened from 10 min to 5 or 2.5 min. Interestingly, although a decrease in time with objects prevented place conditioning, these groups showed a novelty-conditioned increase in activity. Finally, treatment with the dopamine D, antagonist SCH-23390 (0.03 mg/kg) or the dopamine D-2/D-3 antagonist eticlopride (0.1 mg/kg) before the post-conditioning preference test blocked expression of the novel-object place conditioning. Taken together, these experiments establish that the increased preference produced by object-environment pairings reflects a conditioned association between environmental cues and the appetitive effects of receiving access to novel stimuli. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:41 / 50
页数:10
相关论文
共 44 条
[1]   Sensitization to the psychomotor stimulant effects of amphetamine: Modulation by associative learning [J].
Anagnostaras, SG ;
Robinson, TE .
BEHAVIORAL NEUROSCIENCE, 1996, 110 (06) :1397-1414
[2]  
Badiani A, 1998, J NEUROSCI, V18, P10579
[3]   SENSATION SEEKING, SUBSTANCE-ABUSE, AND PSYCHOPATHOLOGY IN TREATMENT-SEEKING AND COMMUNITY COCAINE ABUSERS [J].
BALL, SA ;
CARROLL, KM ;
ROUNSAVILLE, BJ .
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1994, 62 (05) :1053-1057
[4]   Role of Dopamine D-1 and D-2 Receptors in Novelty-Maintained Place Preference [J].
Bardo, M. T. ;
Bowling, S. L. ;
Robinet, P. M. ;
Rowlett, J. K. ;
Lacy, M. ;
Mattingly, B. A. .
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 1993, 1 (1-4) :101-109
[5]   Psychobiology of novelty seeking and drug seeking behavior [J].
Bardo, MT ;
Donohew, RL ;
Harrington, NG .
BEHAVIOURAL BRAIN RESEARCH, 1996, 77 (1-2) :23-43
[6]   Conditioned place preference: what does it add to our preclinical understanding of drug reward? [J].
Bardo, MT ;
Bevins, RA .
PSYCHOPHARMACOLOGY, 2000, 153 (01) :31-43
[7]   Locomotion and conditioned place preference produced by acute intravenous amphetamine: role of dopamine receptors and individual differences in amphetamine self-administration [J].
Bardo, MT ;
Valone, JM ;
Bevins, RA .
PSYCHOPHARMACOLOGY, 1999, 143 (01) :39-46
[8]   Brain regions responsive to novelty in the absence of awareness [J].
Berns, GS ;
Cohen, JD ;
Mintun, MA .
SCIENCE, 1997, 276 (5316) :1272-1275
[9]   Dopamine antagonism in a novel-object recognition and a novel-object place conditioning preparation with rats [J].
Besheer, J ;
Jensen, HC ;
Bevins, RA .
BEHAVIOURAL BRAIN RESEARCH, 1999, 103 (01) :35-44
[10]   The role of environmental familiarization in novel-object preference [J].
Besheer, J ;
Bevins, RA .
BEHAVIOURAL PROCESSES, 2000, 50 (01) :19-29