Monitoring of Treatment-Induced Apoptosis in Oncology with PET and SPECT

被引：26

作者：

Blankenberg, Francis G. ^{[1
]}

机构：

[1] Lucile Salter Packard Childrens Hosp, Div Pediat Radiol, Dept Radiol, FGB, Stanford, CA 94304 USA

来源：

CURRENT PHARMACEUTICAL DESIGN | 2008年 / 14卷 / 28期

关键词：

D O I：

10.2174/138161208786404353

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The early assessment of a solid tumor's response to conventional or new drug therapy to complement or replace current RECIST (or other clinical) criteria remains an elusive goal. The work horse PET tracer F-18-FDG, may represent the most immediate method to track individual tumor response to therapy for many types of cancer. Newer radiotracers such as radiolabeled annexin V, have also shown the ability to selectively localize to tumor cells undergoing apoptosis (programmed cell death) in response to successful treatment in vivo. In this article we will review therapy reduced tumor apoptosis and the radiotracers used to date to image this process in both animal models and clinical trials.

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收藏

页码：2974 / 2982

页数：9

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