Chemical constituents from Inula wissmanniana and their anti-inflammatory activities

被引：33

作者：

Wang, Chunhui ^{[1
]}

Zhang, Xufeng ^{[1
]}

Wei, Panlei ^{[1
]}

Cheng, Xiangrong ^{[1
]}

Ren, Jie ^{[1
]}

Yan, Shikai ^{[1
]}

Zhang, Weidong ^{[1
,2
]}

Jin, Huizi ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Second Mil Med Univ, Sch Pharm, Shanghai 200433, Peoples R China

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2013年 / 36卷 / 12期

关键词：

Inula wissmanniana; Inositol derivatives; Flavonolignans; Thymol derivatives; Anti-inflammatory;

D O I：

10.1007/s12272-013-0143-1

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), one new flavonolignan 23-o-acetylsilychristin A (3), and one new thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds, including ten flavonolignans (5-14) and three thymol derivatives (15-17) were isolated from the aerial part of Inula wissmanniana. The structures of new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic data. All the compounds were isolated from this plant for the first time. The anti-inflammatory activities of the compounds were tested against LPS-induced NO production in RAW 264.7 macrophages.

引用

页码：1516 / 1524

页数：9

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