Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum)

被引：238

作者：

Kim, NC ^{[1
]}

Graf, TN ^{[1
]}

Sparacino, CM ^{[1
]}

Wani, MC ^{[1
]}

Wall, ME ^{[1
]}

机构：

[1] Res Triangle Inst, Nat Prod Lab, Res Triangle Pk, NC 27709 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 10期

关键词：

D O I：

10.1039/b300099k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Complete separation, isolation, and structural characterization of four diastereoisomeric flavonolignans, silybins A (1) and B (2), and isosilybins A (3) and B (4) from the seeds of milk thistle (Silybum marianum) were achieved for the first time using a preparative reversed-phase HPLC method. In addition, three other flavonolignans, silychristin (5) isosilychristin (6) and silydianin (7), and a flavonoid, taxifolin (8) were isolated. Structures, including absolute stereochemistries of 1-4, were confirmed using 2D NMR and CD spectroscopy.

引用

页码：1684 / 1689

页数：6

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