Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists

被引：35

作者：

Beck, JP

Curry, MA

Chorvat, RJ

Fitzgerald, LW

Gilligan, PJ

Zaczek, R

Trainor, GL

机构：

[1] Dupont Pharmaceut Co, Chem & Phys Sci, Wilmington, DE 19880 USA

[2] Dupont Pharmaceut Co, CNS Dis Res, Expt Stn, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00159-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants. (C) 1999 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1185 / 1188

页数：4

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