Correlation between NIH composite skin score, patient-reported skin score, and outcome: results from the Chronic GVHD Consortium

被引：79

作者：

Jacobsohn, David A. ^{[2
]}

Kurland, Brenda F. ^{[1
]}

Pidala, Joseph ^{[3
]}

Inamoto, Yoshihiro ^{[1
]}

Chai, Xiaoyu ^{[1
]}

Palmer, Jeanne M. ^{[4
]}

Arai, Sally ^{[5
]}

Arora, Mukta ^{[6
]}

Jagasia, Madan ^{[7
]}

Cutler, Corey ^{[8
]}

Weisdorf, Daniel ^{[6
]}

Martin, Paul J. ^{[1
]}

Pavletic, Steven Z. ^{[9
]}

Vogelsang, Georgia ^{[10
]}

Lee, Stephanie J. ^{[1
]}

Flowers, Mary E. D. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98109 USA

[2] Childrens Natl Med Ctr, Div Blood & Marrow Transplantat, Washington, DC 20010 USA

[3] Univ S Florida, H Lee Moffitt Canc Ctr, Tampa, FL 33682 USA

[4] Med Coll Wisconsin, Div Hematol Oncol, Milwaukee, WI 53226 USA

[5] Stanford Univ, Med Ctr, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA

[6] Univ Minnesota, Blood & Marrow Transplant Program, Minneapolis, MN USA

[7] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA

[8] Dana Farber Canc Inst, Boston, MA 02115 USA

[9] NCI, NIH, Bethesda, MD 20892 USA

[10] Johns Hopkins Univ Hosp, Dept Oncol, Baltimore, MD 21287 USA

来源：

BLOOD | 2012年 / 120卷 / 13期

基金：

美国国家卫生研究院;

关键词：

VERSUS-HOST-DISEASE; CONSENSUS DEVELOPMENT PROJECT; WORKING GROUP-REPORT; MARROW-TRANSPLANTATION; THERAPEUTIC RESPONSE; CLINICAL-TRIALS; BONE-MARROW; VALIDATION; CRITERIA; RELAPSE;

D O I：

10.1182/blood-2012-04-424135

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are no validated criteria to measure skin response in chronic GVHD. In a prospectively assembled, multicenter cohort of patients with chronic GVHD (N = 458), we looked for correlation of change in several different scales recommended by the National Institutes of Health (NIH) Consensus with clinician and patient perception of change and overall survival. Of the clinician scales, the NIH composite 0-3 skin score was the only one that correlated with both clinician and patient perception of improvement or worsening. Of the patient-reported scales, the skin subscale of the Lee Symptom Scale was the only one that correlated with both clinician and patient perception of improvement or worsening. At study entry, NIH skin score 3 and Lee skin symptom score > 15 were both associated with worse overall survival. Worsening of NIH skin score at 6 months was associated with worse overall survival. Improvement in the Lee skin symptom score at 6 months was associated with improved overall survival. Our findings support the use of the NIH composite 0-3 skin score and the Lee skin symptom score as simple and sensitive measures to evaluate skin involvement in clinical trials as well as in the clinical monitoring of patients with cutaneous chronic GVHD. (Blood. 2012; 120(13):2545-2552)

引用

页码：2545 / 2552

页数：8

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