A single nucleotide is a sufficient 5' untranslated region for translation in an eukaryotic in vitro system

被引：21

作者：

Hughes, MJG ^{[1
]}

Andrews, DW ^{[1
]}

机构：

[1] MCMASTER UNIV,DEPT BIOCHEM,HAMILTON,ON L8N 3Z5,CANADA

来源：

FEBS LETTERS | 1997年 / 414卷 / 01期

关键词：

translation initiation; 5' untranslated region; consensus sequence;

D O I：

10.1016/S0014-5793(97)00965-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 5' untranslated region of an RNA molecule is thought to play an important role in the regulation of translation, Following a recent report that a single nucleotide is sufficient to act in this role in the unicellular organism Giardia, we show that this is also the case for a mammalian in vitro system. These results also demonstrate that an RNA can initiate translation from a start codon where an ideal translational consensus sequence is impossible. (C) 1997 Federation of European Biochemical Societies.

引用

页码：19 / 22

页数：4

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