Isolation of 13 new ritterazines from the tunicate Ritterella tokioka and chemical transformation of ritterazine B

被引:84
作者
Fukuzawa, S [1 ]
Matsunaga, S [1 ]
Fusetani, N [1 ]
机构
[1] UNIV TOKYO,GRAD SCH AGR & LIFE SCI,LAB AQUAT NAT PROD CHEM,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1021/jo970091r
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Thirteen reitterazines, ritterazines N-Z (2-14), were isolated from the tunicate Ritterella tokioka. Chemical transformation of ritterazine B, the most active among the ritterazines, by reduction, oxidation, methanolysis, and acetylation furnished compounds 20, 21, 23, and 25-29. Cytotoxicity of 26 natural products and chemically modified ritterazine B disclosed important structural features of the ritterazines for cytotoxic activity.
引用
收藏
页码:4484 / 4491
页数:8
相关论文
共 18 条