Nitric oxide, platelet function, myocardial infarction and reperfusion therapies

被引：40

作者：

Alonso, D ^{[1
]}

Radomski, MW ^{[1
]}

机构：

[1] Univ Texas, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA

来源：

HEART FAILURE REVIEWS | 2003年 / 8卷 / 01期

基金：

加拿大健康研究院;

关键词：

nitric oxide; platelet function; myocardial infarction; reperfusion;

D O I：

10.1023/A:1022194921040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelets play an important role in physiologic hemostasis and pathologic thrombosis that complicate the course of vascular disorders. A number of platelet functions including adhesion, aggregation and recruitment are controlled by nitric oxide (NO) generated by platelets and the endothelial cells. Derangements in this generation may contribute to the pathogenesis of thrombotic complications of vascular disorders. The pharmacologic supplementation of the diseased vasculature with drugs releasing NO may help to restore the hemostatic balance.

引用

页码：47 / 54

页数：8

共 97 条

[1] Inhaled nitric oxide increases coronary artery patency after thrombolysis
Adrie, C
Bloch, KD
Moreno, PR
Hurford, WE
Guerrero, JL
Holt, R
Zapol, WM
Gold, HK
Semigran, MJ
[J]. CIRCULATION, 1996, 94 (08) : 1919 - 1926
[2] ANDREWS R, 1994, BRIT HEART J, V72, P575
[3] Beckman J., 1994, BIOCHEMIST, V16, P8
[4] Current status of platelet NO synthases
Berkels, R
Stockklauser, K
Rosen, P
Rosen, R
[J]. THROMBOSIS RESEARCH, 1997, 87 (01) : 51 - 55
[5] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME
BREDT, DS
SNYDER, SH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 682 - 685
[6] Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite
Brown, AS
Moro, MA
Masse, JM
Cramer, EM
Radomski, M
Darley-Usmar', V
[J]. CARDIOVASCULAR RESEARCH, 1998, 40 (02) : 380 - 388
[7] Effect of supplemental oral L-arginine on exercise capacity in patients with stable angina pectoris
Ceremuzynski, L
Chamiec, T
HerbaczynskaCedro, K
[J]. AMERICAN JOURNAL OF CARDIOLOGY, 1997, 80 (03) : 331 - &
[8] Further evidence of the presence of constitutive and inducible nitric oxide synthase isoforms in human platelets
Chen, LY
Metha, JL
[J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1996, 27 (01) : 154 - 158
[9] NITRIC-OXIDE REACTS WITH INTRACELLULAR GLUTATHIONE AND ACTIVATES THE HEXOSE-MONOPHOSPHATE SHUNT IN HUMAN NEUTROPHILS - EVIDENCE FOR S-NITROSOGLUTATHIONE AS A BIOACTIVE INTERMEDIARY
CLANCY, RM
LEVARTOVSKY, D
LESZCZYNSKAPIZIAK, J
YEGUDIN, J
ABRAMSON, SB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) : 3680 - 3684
[10] Coller BS, 1997, THROMB HAEMOSTASIS, V78, P730

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