Missing Heritability and GWAS Utility

被引:58
作者
Bogardus, Clifton [1 ]
机构
[1] NIDDK, Phoenix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ USA
关键词
BODY-MASS INDEX; HUMAN OBESITY; COMMON; POPULATION; CHILDHOOD; VARIANTS; MC4R; RISK;
D O I
10.1038/oby.2008.613
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:209 / 210
页数:2
相关论文
共 14 条
[1]   A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].
Frayling, Timothy M. ;
Timpson, Nicholas J. ;
Weedon, Michael N. ;
Zeggini, Eleftheria ;
Freathy, Rachel M. ;
Lindgren, Cecilia M. ;
Perry, John R. B. ;
Elliott, Katherine S. ;
Lango, Hana ;
Rayner, Nigel W. ;
Shields, Beverley ;
Harries, Lorna W. ;
Barrett, Jeffrey C. ;
Ellard, Sian ;
Groves, Christopher J. ;
Knight, Bridget ;
Patch, Ann-Marie ;
Ness, Andrew R. ;
Ebrahim, Shah ;
Lawlor, Debbie A. ;
Ring, Susan M. ;
Ben-Shlomo, Yoav ;
Jarvelin, Marjo-Riitta ;
Sovio, Ulla ;
Bennett, Amanda J. ;
Melzer, David ;
Ferrucci, Luigi ;
Loos, Ruth J. F. ;
Barroso, Ines ;
Wareham, Nicholas J. ;
Karpe, Fredrik ;
Owen, Katharine R. ;
Cardon, Lon R. ;
Walker, Mark ;
Hitman, Graham A. ;
Palmer, Colin N. A. ;
Doney, Alex S. F. ;
Morris, Andrew D. ;
Smith, George Davey ;
Hattersley, Andrew T. ;
McCarthy, Mark I. .
SCIENCE, 2007, 316 (5826) :889-894
[2]   Childhood obesity: Genetic and environmental overlap with normal-range BMI [J].
Haworth, Claire M. A. ;
Plomin, Robert ;
Carnell, Susan ;
Wardle, Jane .
OBESITY, 2008, 16 (07) :1585-1590
[3]   The epidemiology of obesity: the size of the problem [J].
James, W. P. T. .
JOURNAL OF INTERNAL MEDICINE, 2008, 263 (04) :336-352
[4]   Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant [J].
Krakoff, Jonathan ;
Ma, Lijun ;
Kobes, Sayuko ;
Knowler, William C. ;
Hanson, Robert L. ;
Bogardus, Clifton ;
Baier, Leslie J. .
DIABETES, 2008, 57 (12) :3267-3272
[5]   Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk [J].
Lango, Hana ;
Palmer, Colin N. A. ;
Morris, Andrew D. ;
Zeggini, Eleftheria ;
Hattersley, Andrew T. ;
McCarthy, Mark I. ;
Frayling, Timothy M. ;
Weedon, Michael N. .
DIABETES, 2008, 57 (11) :3129-3135
[6]   Common variants near MC4R are associated with fat mass, weight and risk of obesity [J].
Loos, Ruth J. F. ;
Lindgren, Cecilia M. ;
Li, Shengxu ;
Wheeler, Eleanor ;
Zhao, Jing Hua ;
Prokopenko, Inga ;
Inouye, Michael ;
Freathy, Rachel M. ;
Attwood, Antony P. ;
Beckmann, Jacques S. ;
Berndt, Sonja I. ;
Bergmann, Sven ;
Bennett, Amanda J. ;
Bingham, Sheila A. ;
Bochud, Murielle ;
Brown, Morris ;
Cauchi, Stephane ;
Connell, John M. ;
Cooper, Cyrus ;
Smith, George Davey ;
Day, Ian ;
Dina, Christian ;
De, Subhajyoti ;
Dermitzakis, Emmanouil T. ;
Doney, Alex S. F. ;
Elliott, Katherine S. ;
Elliott, Paul ;
Evans, David M. ;
Farooqi, I. Sadaf ;
Froguel, Philippe ;
Ghori, Jilur ;
Groves, Christopher J. ;
Gwilliam, Rhian ;
Hadley, David ;
Hall, Alistair S. ;
Hattersley, Andrew T. ;
Hebebrand, Johannes ;
Heid, Iris M. ;
Herrera, Blanca ;
Hinney, Anke ;
Hunt, Sarah E. ;
Jarvelin, Marjo-Riitta ;
Johnson, Toby ;
Jolley, Jennifer D. M. ;
Karpe, Fredrik ;
Keniry, Andrew ;
Khaw, Kay-Tee ;
Luben, Robert N. ;
Mangino, Massimo ;
Marchini, Jonathan .
NATURE GENETICS, 2008, 40 (06) :768-775
[7]   Melanocortin 4 receptor mutations in a large cohort of severely obese adults: Prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating [J].
Lubrano-Berthelier, C ;
Dubern, B ;
Lacorte, JM ;
Picard, F ;
Shapiro, A ;
Zhang, SM ;
Bertrais, S ;
Hercberg, S ;
Basdevant, A ;
Clement, K ;
Vaisse, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (05) :1811-1818
[8]   Integrated detection and population-genetic analysis of SNPs and copy number variation [J].
McCarroll, Steven A. ;
Kuruvilla, Finny G. ;
Korn, Joshua M. ;
Cawley, Simon ;
Nemesh, James ;
Wysoker, Alec ;
Shapero, Michael H. ;
de Bakker, Paul I. W. ;
Maller, Julian B. ;
Kirby, Andrew ;
Elliott, Amanda L. ;
Parkin, Melissa ;
Hubbell, Earl ;
Webster, Teresa ;
Mei, Rui ;
Veitch, James ;
Collins, Patrick J. ;
Handsaker, Robert ;
Lincoln, Steve ;
Nizzari, Marcia ;
Blume, John ;
Jones, Keith W. ;
Rava, Rich ;
Daly, Mark J. ;
Gabriel, Stacey B. ;
Altshuler, David .
NATURE GENETICS, 2008, 40 (10) :1166-1174
[9]   Lessons from Extreme Human Obesity: Monogenic Disorders [J].
Ranadive, Sayali A. ;
Vaisse, Christian .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2008, 37 (03) :733-+
[10]   EFFECTS OF A TRADITIONAL LIFE-STYLE ON OBESITY IN PIMA-INDIANS [J].
RAVUSSIN, E ;
BENNETT, PH ;
VALENCIA, ME ;
SCHULZ, LO ;
ESPARZA, J .
DIABETES CARE, 1994, 17 (09) :1067-1074