Manganese: a new contrast agent for lung imaging?

被引：6

作者：

Gobbo, Oliviero L. ^{[1
]}

Zurek, Magdalena ^{[2
]}

Tewes, Frederic ^{[1
]}

Ehrhardt, Carsten ^{[1
]}

Cremillieux, Yannick ^{[2
]}

机构：

[1] Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Dublin, Ireland

[2] Univ Lyon 1, Creatis LRMN, F-69622 Villeurbanne, France

来源：

CONTRAST MEDIA & MOLECULAR IMAGING | 2012年 / 7卷 / 06期

基金：

爱尔兰科学基金会;

关键词：

MEMRI; lung imaging; manganese; aerosol contrast agent; UTE lung MRI; RESONANCE; MEMRI; MRI; VENTILATION; TOXICITY; NEUROTOXICITY;

D O I：

10.1002/cmmi.1483

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging (MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI (MEMRI) technique has not been associated with pulmonary MRI. Here, we evaluated T1-enhancement in the rat lung after a manganese instillation, using a 4.7 T magnet with a radial ultrashort echo time sequence. Our data showed that the signal intensity was increased in lungs receiving a manganese solution compared with a control solution to the lungs. MR signal enhancements above 30% were measured in lung parenchyma following 200 mu l instillation of a 1 mm manganese chloride solution. MEMRI, therefore, may be a useful novel tool for enhancing signal intensity and image contrast in lung tissue. Copyright (c) 2012 John Wiley & Sons, Ltd.

引用

页码：542 / 546

页数：5

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