SpliceNest: visualizing gene structure and alternative splicing based on EST clusters

被引：31

作者：

Coward, E ^{[1
]}

Haas, SA ^{[1
]}

Vingron, M ^{[1
]}

机构：

[1] Max Planck Inst Mol Genet, Dept Computat Mol Biol, D-14195 Berlin, Germany

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 01期

关键词：

D O I：

10.1016/S0168-9525(01)02525-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Messenger RNA sequences, expressed sequence tags (ESTs), and, in particular, consensus sequences of clustered ESTs provide valuable information about splice variants of genes. We have mapped such (predicted) human mRNA sequences onto human genomic DNA to compute gene structure and splice variants. The results of this computation have been collected in a public database, SpliceNest, with a web-based, interactive graphical user interface. The quality of the presented data profits from previous assembly of ESTs and allows for analysis of gene structure and detection of splice variants in conjunction with the clones and libraries that indicated variants.

引用

页码：53 / 55

页数：3

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