Role of biologically active sphingolipids in tumor growth

被引：18

作者：

Dyatlovitskaya, EV ^{[1
]}

Kandyba, AG ^{[1
]}

机构：

[1] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2006年 / 71卷 / 01期

关键词：

gangliosides; glucosylceramide; sphingosine; sphingolipids; sphingomyelin; sphingosine-l-phosphate; ceramide; tumor;

D O I：

10.1134/S0006297906010020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review highlights the literature on the effects of biologically active sphingolipids (sphingosine, ceramide, sphingomyelin, glucosylceramide, gangliosides GM 1, GM2, GM3, GD3, etc.) on proliferation, apoptosis, metastases, and invasiveness of tumor cells and the putative role of sphingolipids in chemotherapy of malignant tumors.

引用

页码：10 / 17

页数：8

共 141 条

[1] Sphingoid bases and ceramide induce apoptosis in HT-29 and HCT-116 human colon cancer cells [J].

Ahn, EH ;

Schroeder, JJ .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2002, 227 (05) :345-353

[2] Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells [J].

Akao, Y ;

Kusakabe, S ;

Banno, Y ;

Kito, M ;

Nakagawa, Y ;

Tamiya-Koizumi, K ;

Hattori, M ;

Sawada, M ;

Hirabayasi, Y ;

Ohishi, N ;

Nozawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 294 (02) :363-370

[3]

Alessenko AV, 1998, BIOCHEMISTRY-MOSCOW+, V63, P62

[4] Generation of human monoclonal antibodies against ganglioside antigens and their applications in the diagnosis and therapy of cancer [J].

Alfonso, M ;

Zeuthen, J .

ACTA ONCOLOGICA, 1996, 35 (03) :287-295

[5]

Andreasyan GO, 1996, VOP MED KHIM, V42, P248

[6]

ANKAWA K, 2003, J BIOL CHEM, V278, P32841

[7] Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells [J].

Beil, M ;

Micoulet, A ;

von Wichert, G ;

Paschke, S ;

Walther, P ;

Omary, MB ;

Van Veldhoven, PP ;

Gern, U ;

Wolff-Hieber, E ;

Eggermann, J ;

Waltenberger, J ;

Adler, G ;

Spatz, J ;

Seufferlein, T .

NATURE CELL BIOLOGY, 2003, 5 (09) :803-811

[8]

Berger A, 1996, MOL PHARMACOL, V50, P451

[9] Dietary sphingolipids in colorectal cancer prevention [J].

Berra, B ;

Colombo, I ;

Sottocornola, E ;

Giacosa, A .

EUROPEAN JOURNAL OF CANCER PREVENTION, 2002, 11 (02) :193-197

[10] Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis [J].

Birbes, H ;

El Bawab, S ;

Hannun, YA ;

Obeid, LM .

FASEB JOURNAL, 2001, 15 (14) :2669-2679

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