Durumolides A-E, anti-inflammatory and antibacterial cembranolides from the soft coral Lobophytum durum

被引：59

作者：

Cheng, Shi-Yie ^{[1
]}

Wen, Zhi-Hong ^{[1
]}

Chiou, Shu-Fen ^{[1
]}

Hsu, Chi-Hsin ^{[1
,5
]}

Wang, Shang-Kewi ^{[2
]}

Dai, Chang-Feng ^{[3
]}

Chiang, Michael Y. ^{[4
]}

Duh, Chang-Yih ^{[1
,5
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung 807, Taiwan

[3] Natl Taiwan Univ, Inst Oceanog, Taipei 10764, Taiwan

[4] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[5] Natl Sun Yat Sen Univ, Ctr Asia Pacific Marine Res, Kaohsiung 804, Taiwan

来源：

TETRAHEDRON | 2008年 / 64卷 / 41期

关键词：

Lobophytum durum; cembranoid; alpha-methylene-gamma-lactone; anti-inflammatory effects; antibacterial activities; HCMV endonuclease activity;

D O I：

10.1016/j.tet.2008.07.104

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Chemical investigations on the acetone extract of the soft coral Lobophytum durum have afforded five new cembranoids with a trans-fused alpha-methylene-gamma-lactone, durumolides A-E (1, 6, and 8-10), and five previously characterized cembrane-based diterpenoids (2-5 and 7). The Structures of the isolated metabolites were elucidated through extensive spectroscopic analyses, while the relative stereochemistry of 4 was confirmed by X-ray diffraction analyses. Moreover, the absolute configurations of 3-5 and 8 were established by application of modified Mosher's method. The anti-inflammatory effects, antibacterial activities, and inhibition assay of HCMV (Human cytomegalovirus) endonuclease activity of these isolated metabolites 1-10 were evaluated in Vitro. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：9698 / 9704

页数：7

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