Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer

被引：248

作者：

Takayama, Ken-ichi ^{[1
,2
,3
]}

Horie-Inoue, Kuniko ^{[3
]}

Katayama, Shintaro ^{[4
]}

Suzuki, Takashi ^{[5
]}

Tsutsumi, Shuichi ^{[6
]}

Ikeda, Kazuhiro ^{[3
]}

Urano, Tomohiko ^{[1
,2
,3
]}

Fujimura, Tetsuya ^{[7
]}

Takagi, Kiyoshi ^{[5
]}

Takahashi, Satoru ^{[8
]}

Homma, Yukio ^{[7
]}

Ouchi, Yasuyoshi ^{[2
]}

Aburatani, Hiroyuki ^{[6
]}

Hayashizaki, Yoshihide ^{[4
]}

Inoue, Satoshi ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Antiaging Med, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Bunkyo Ku, Tokyo 1138655, Japan

[3] Saitama Med Univ, Res Ctr Genom Med, Div Gene Regulat & Signal Transduct, Hidaka, Saitama, Japan

[4] RIKEN, Prevent Med & Diag Innovat Program, Wako, Saitama, Japan

[5] Tohoku Univ, Grad Sch Med, Dept Pathol, Sendai, Miyagi 980, Japan

[6] Univ Tokyo, Res Ctr Adv Sci & Technol, Genome Sci Div, Meguro Ku, Tokyo 1138655, Japan

[7] Univ Tokyo, Grad Sch Med, Dept Urol, Bunkyo Ku, Tokyo 1138655, Japan

[8] Nihon Univ, Sch Med, Dept Urol, Itabashi Ku, Tokyo, Japan

来源：

EMBO JOURNAL | 2013年 / 32卷 / 12期

关键词：

androgen; non-coding RNA; prostate cancer; CHROMATIN IMMUNOPRECIPITATION; TRANSCRIPTIONAL REGULATION; ANTISENSE TRANSCRIPTION; RECEPTOR; GENE; COREPRESSOR; EXPRESSION; REVEALS; BINDING; PSF;

D O I：

10.1038/emboj.2013.99

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

High-throughput techniques have identified numerous antisense (AS) transcripts and long non-coding RNAs (ncRNAs). However, their significance in cancer biology remains largely unknown. Here, we report an androgen-responsive long ncRNA, CTBP1-AS, located in the AS region of C-terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor. CTBP1-AS is predominantly localized in the nucleus and its expression is generally upregulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumour growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by inhibiting tumour-suppressor genes via the PSF-dependent mechanism thus promoting cell cycle progression. Our findings provide new insights into the functions of ncRNAs that directly contribute to prostate cancer progression.

引用

页码：1665 / 1680

页数：16

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