National addictions vigilance intervention and prevention program (NAVIPPRO™): a real-time, product-specific, public health surveillance system for monitoring prescription drug abuse

被引：81

作者：

Butler, Stephen F. ^{[1
]}

Budman, Simon H. ^{[1
]}

Licari, Andrea ^{[1
]}

Cassidy, Theresa A. ^{[1
]}

Lioy, Katherine ^{[1
]}

Dickinson, James ^{[1
]}

Brownstein, John S. ^{[1
]}

Benneyan, James C. ^{[2
]}

Green, Traci Craig ^{[3
]}

Katz, Nathaniel ^{[1
,4
,5
]}

机构：

[1] Inflexxion Inc, Newton, MA USA

[2] Northeastern Univ, Coll Engn, Boston, MA 02115 USA

[3] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06520 USA

[4] Tufts Univ, Sch Med, Boston, MA 02111 USA

[5] Analges Res, Newton, MA 02464 USA

来源：

PHARMACOEPIDEMIOLOGY AND DRUG SAFETY | 2008年 / 17卷 / 12期

关键词：

post-marketing surveillance; pharmaceutical surveillance; drug surveillance; substance abuse treatment;

D O I：

10.1002/pds.1659

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Purpose The National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO (TM)) is a scientific, comprehensive risk management program for scheduled therapeutics. NAVIPPRO (TM) provides post-marketing surveillance, signal detection, signal verification and prevention and intervention programs. Here we focus on one component of NAVIPPRO (TM) surveillance, the Addiction Severity Index-Multi media Version (R) (ASI-MV (R)) Connect, a continuous, real-time, national data stream that assesses pharmaceutical abuse by patients entering substance abuse treatment by collecting product-specific, geographically-detailed information. Methods We evaluate population characteristics for data collected through the ASI-MV (R) Connect in 2007 and 2008 and assess the representativeness, geographic coverage, and timeliness of report of the data. Analyses based on 41923 admissions to 265 treatment centers in 29 states were conducted on product-specific opioid abuse rates, source of drug, and route of administration. Results ASI-MV (R) Connect data revealed that 11.5% of patients reported abuse of at least one opioid analgesic product in the 30 days prior to entering substance abuse treatment; differences were observed among sub-populations of prescription opioid abusers, among products, and also within various geographic locations. Conclusions The ASI-MV (R) Connect component of NAVIPPRO (TM) represents a potentially valuable data stream for post-marketing surveillance of prescription drugs. Analyses conducted with data obtained from the ASI-MV (R) Connect allow for the characterization of product-specific and geospatial differences for drug abuse and can serve as a tool to monitor responses of the abuse population to newly developed "abuse deterrent" drug formulations. Additional data, evaluation, and comparison to other systems are important next steps in establishing NAVIPPRO (TM) as a comprehensive. post-marketing surveillance system for prescription drugs. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：1142 / 1154

页数：13

共 31 条

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