Semisynthesis and cytotoxicity of amino acetogenins and derivatives

被引：18

作者：

Duret, P

Hocquemiller, R

Gantier, JC

Figadère, B ^{[1
]}

机构：

[1] Univ Paris Sud, Fac Pharm, CNRS, Lab Pharmacognosie,BIOCIS, F-92296 Chatenay Malabry, France

[2] Univ Paris Sud, Fac Pharm, Parasitol Lab, F-92296 Chatenay Malabry, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 09期

关键词：

annonaceous acetogenins; semisynthesis; amino-derivatives; cytotoxicity;

D O I：

10.1016/S0968-0896(99)00135-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Semisynthetic derivatives were prepared from two natural annonaceous acetogenins, rolliniastatin-1 and squamocin, and their cytotoxicity was evaluated. Amino derivatives show decreased bioactivity. Isorolliniastatin-1 was found to be much less toxic than rolliniastatin-1 after intraperitoneal administration to mice, although the in vitro cytotoxicity of both compounds was comparable (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1821 / 1826

页数：6

共 39 条

[1] MODE OF ACTION OF BULLATACIN - A POTENT ANTITUMOR AND PESTICIDAL ANNONACEOUS ACETOGENIN [J].