Epimerization of annonaceous acetogenins under basic conditions

被引：44

作者：

Duret, P ^{[1
]}

Figadere, B ^{[1
]}

Hocquemiller, R ^{[1
]}

Cave, A ^{[1
]}

机构：

[1] UNIV PARIS SUD, ASSOCIE CNRS BIOCIS, LAB PHARMACOGNOSIE, FAC PHARM, F-92296 CHATENAY MALABRY, FRANCE

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 51期

关键词：

D O I：

10.1016/S0040-4039(97)10390-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In basic conditions, non-4-hydroxylated annonaceous acetogenins may be epimerized by light basic treatment. The two epimers are inseparable by HPLC, have identical spectroscopic data CMS, IR, UV, H-1 and C-13 NMR). However, specific rotation of the epimeric mixture and enzymatic oxidation after chemical degradation, allow us to characterize this epimerization. In the same reaction conditions, 4-hydroxylated annonaceous acetogenins led to isoacetogenins. (C) 1997 Elsevier Science Ltd.

引用

页码：8849 / 8852

页数：4

共 13 条

[1]

Cave A, 1997, Fortschr Chem Org Naturst, V70, P81

[2]

CHEN WS, 1995, CHINESE J ORG CHEM, V15, P85

[3] ACETOGENINS OF THE ANNONACEAE .20. BIOACTIVE ACETOGENINS FROM SEEDS OF ANNONA-CHERIMOLIA [J].