Dynamic Display of Bioactivity through Host-Guest Chemistry

被引：113

作者：

Boekhoven, Job ^{[4
]}

Perez, Charles M. Rubert ^{[4
]}

Sur, Shantanu ^{[4
]}

Worthy, Amanda ^{[4
]}

Stupp, Samuel I. ^{[1
,2
,3
]}

机构：

[1] Northwestern Univ, Inst BioNanotechnol, Dept Mat Sci & Engn, Chicago, IL 60611 USA

[2] Northwestern Univ, Inst BioNanotechnol, Dept Chem, Chicago, IL 60611 USA

[3] Northwestern Univ, Inst BioNanotechnol, Dept Med, Chicago, IL 60611 USA

[4] Northwestern Univ, Inst BioNanotechnol Med, Chicago, IL 60611 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 46期

关键词：

biological signaling; cell adhesion; dynamics; host-guest chemistry; supramolecular chemistry; BETA-CYCLODEXTRIN; CELL-ADHESION; ATTACHMENT; FORCES; MATRIX;

D O I：

10.1002/anie.201306278

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A molecular host, β-cyclodextrin (CD), covalently attached to an alginate matrix enables dynamic control of cue display through exchange of guest molecules. Addition of soluble RGDS-containing guest molecules to culture medium induced focal adhesion formation and spreading of 3T3 fibroblasts on the otherwise non-spreading alginate surface. The spreading could be reversed by adding competitive guest molecules bearing the mutated non-bioactive sequence RGES. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12077 / 12080

页数：4

共 34 条

[1]

Micropatterning Alginate Substrates for In Vitro Cardiovascular Muscle on a Chip [J].