Edaravone's free radical scavenging mechanisms of neuroprotection against cerebral ischemia: review of the literature

被引：87

作者：

Ren, Yanxin ^{[1
]}

Wei, Bing ^{[1
]}

Song, Xirui ^{[1
]}

An, Nan ^{[1
]}

Zhou, Yiying ^{[1
]}

Jin, Xinxin ^{[1
]}

Zhang, Yuyang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Life Sci & Biopharmaceut, Shenyang 110016, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2015年 / 125卷 / 08期

关键词：

Edaravone; free radicals; oxidative stress; cerebral ischemia; neuroprotection; NITRIC-OXIDE; OXIDATIVE STRESS; ANTIOXIDANT EDARAVONE; SINGLET OXYGEN; SPINAL-CORD; STROKE; DAMAGE; MCI-186; IMPROVES; THERAPY;

D O I：

10.3109/00207454.2014.959121

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Free radicals and oxidative stress play key roles in cerebral ischemic pathogenesis and represent pharmacological targets for treatment. Edaravone (Edv), one of antioxidant agents that have been used in acute ischemic stroke in both clinical settings and animal experiments, exerts neuroprotective effect on ischemic injured brains. This review is aimed to elaborate the latest molecular mechanisms of the neuroprotection of Edv on cerebral ischemia and provide reasonable evidence in its clinical application. It is found that Edv has neuroprotective influence on cerebral ischemia, which is closely related to the facets of scavenging reactive oxygen species (ROS), hydroxyl radical (center dot OH) and reactive nitrogen species (RNS). And it is a good antioxidant agent that can be safely used in the treatment of cerebral ischemia and chronic neurodegenerative disorders as well as other ischemia/reperfusion (I/R)-related diseases. The combination of Edv with thrombolytic therapy also can be applied in clinical settings and will be greatly beneficial to patients with stroke.

引用

页码：555 / 565

页数：11

共 81 条

[1]

Edaravone ameliorates oxidative stress associated cholinergic dysfunction and limits apoptotic response following focal cerebral ischemia in rat [J].