Retinoids: Potent regulators of metabolism

被引：71

作者：

Brun, Pierre-Jacques ^{[1
]}

Yang, Kryscilla Jian Zhang ^{[1
]}

Lee, Seung-Ah ^{[1
]}

Yuen, Jason J. ^{[1
]}

Blaner, William S. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10032 USA

来源：

BIOFACTORS | 2013年 / 39卷 / 02期

基金：

美国国家卫生研究院;

关键词：

vitamin A; metabolic disease; glucose; pancreas; adipose tissue; VITAMIN-A-DEFICIENCY; STIMULATED INSULIN-SECRETION; NONALCOHOLIC FATTY LIVER; DIET-INDUCED OBESITY; ACTIVATED RECEPTOR-BETA/DELTA; PANCREATIC BETA-CELLS; LIPASE KNOCKOUT MICE; WHITE ADIPOSE-TISSUE; ACID RECEPTOR; GENE-EXPRESSION;

D O I：

10.1002/biof.1056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Retinoids (vitamin A and its analogs) are highly potent regulators of cell differentiation, cell proliferation, and apoptosis. Because of these activities, retinoids have been most extensively studied in the contexts of embryonic development and of proliferative diseases, especially cancer and skin disease. Recently, there has been considerable new research interest focused on gaining understanding of the roles that retinoids and/or retinoid-related proteins may have in the development of metabolic diseases, primarily obesity, diabetes, and dyslipidemia. This review will summarize recent advances that have been made in these areas, focusing on the role of retinoids in modulating adipogenesis, the roles of retinoids and retinoid-related proteins as signaling molecules linking obesity with the development of type II diabetes, the roles of retinoids in pancreatic -cell biology/insulin secretion, and the actions of retinoids in hepatic steatosis. (c) 2012 BioFactors, 2013

引用

页码：151 / 163

页数：13

共 102 条

[1]

Serum retinol-binding protein 4 concentration and its ratio to serum retinol are associated with obesity and metabolic syndrome components in children [J].