Preparation of optically active α,α-difluoro-β-hydroxyketones

被引：25

作者：

Iseki, K ^{[1
]}

Asada, D ^{[1
]}

Kuroki, Y ^{[1
]}

机构：

[1] Daikin Ind, MEC Lab, Tsukuba, Ibaraki 3050841, Japan

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1999年 / 97卷 / 1-2期

关键词：

fluorinated molecules; asymmetric synthesis; nucleophilic addition;

D O I：

10.1016/S0022-1139(99)00033-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The stereoselective synthesis of alpha,alpha-difluoro-beta-hydroxyketones of high enantiomeric purity is described starting from optically active alpha,alpha-difluoro-beta-hydroxy esters. The esters were converted to the corresponding N-methoxy-N-methyl amides, which were treated with Grignard and organolithium reagents to provide the alpha,alpha-difluoro-beta-hydroxyketones with up to 100% ee. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：85 / 89

页数：5

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