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Immunology - Deficient cellular immunity - Finding and fixing the defects

被引：79
作者：
Greenberg, PD [1 ]
Riddell, SR
机构：
[1] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA
[2] Univ Washington, Dept Med, Seattle, WA 98195 USA
[3] Univ Washington, Dept Immunol, Seattle, WA 98195 USA
来源：
SCIENCE | 1999年 / 285卷 / 5427期
关键词：
D O I：
10.1126/science.285.5427.546
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The critical role of cellular immunity in resistance to infectious diseases is glaringly revealed by life-threatening infections if T cell function is disrupted by an inherited or acquired immunodeficiency. Although treatment has historically focused on infectious complications, understanding of the cellular and molecular basis of immunodeficiency and technologies useful for enhancing cellular immunity have both been rapidly; evolving. A new era of molecular and cellular therapy is emerging as approaches to correct abnormal genes, the loss of T cell subpopulations, and aberrant T cell homeostasis make the transition from bench to bedside.
引用
收藏
页码：546 / 551
页数：8
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