Tools in the Assessment of Sarcopenia

被引：196

作者：

Cooper, C. ^{[1
,2
,3
]}

Fielding, R. ^{[4
]}

Visser, M. ^{[5
,6
]}

van Loon, L. J. ^{[7
]}

Rolland, Y. ^{[8
]}

Orwoll, E. ^{[9
]}

Reid, K. ^{[4
]}

Boonen, S. ^{[10
,11
,12
,13
]}

Dere, W. ^{[14
]}

Epstein, S. ^{[15
]}

Mitlak, B. ^{[16
]}

Tsouderos, Y. ^{[17
]}

Sayer, A. A. ^{[1
]}

Rizzoli, R. ^{[18
]}

Reginster, J. Y. ^{[19
]}

Kanis, J. A. ^{[20
]}

机构：

[1] Univ Southampton, Southampton Gen Hosp, MRC Lifecourse Epidemiol Unit, Southampton SO16 6YD, Hants, England

[2] Univ Southampton, NIHR Nutr Biomed Res Ctr, Southampton SO16 6YD, Hants, England

[3] Univ Oxford, NIHR Musculoskeletal Biomed Res Unit, Oxford OX3 7LD, England

[4] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[5] Vrije Univ Amsterdam, VU Univ Med Ctr, Dept Hlth Sci, Amsterdam, Netherlands

[6] EMGO Inst, Amsterdam, Netherlands

[7] Maastricht Univ Med Ctr, Dept Human Movement Sci, NL-6200 MD Maastricht, Netherlands

[8] Toulouse Univ Hosp, Dept Geriatr Med, INSERM U1027, Gerontopole Toulouse, Toulouse, France

[9] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97239 USA

[10] Univ Louvain, Div Gerontol & Geriatr, Louvain, Belgium

[11] Univ Louvain, Ctr Musculoskeletal Res, Dept Expt Med, Louvain, Belgium

[12] Leuven Univ Hosp, Div Geriatr Med, Louvain, Belgium

[13] Leuven Univ Hosp, Ctr Metab Bone Dis, Dept Internal Med, Louvain, Belgium

[14] Amgen Ltd, Uxbridge, Middx, England

[15] Mt Sinai Sch Med, Div Endocrinol, New York, NY USA

[16] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA

[17] Inst Rech Int Servier, F-92284 Suresnes, France

[18] Univ Hosp Geneva, Div Bone Dis, Geneva, Switzerland

[19] CHU Ctr Ville, Bone & Cartilage Metab Unit, Liege, Belgium

[20] Univ Sheffield, Sch Med, WHO Collaborating Ctr Metab Bone Dis, Sheffield S10 2RX, S Yorkshire, England

来源：

CALCIFIED TISSUE INTERNATIONAL | 2013年 / 93卷 / 03期

关键词：

Sarcopenia; Muscle mass; Muscle strength; Muscle power; Muscle fatigue; Older adults; X-RAY ABSORPTIOMETRY; SKELETAL-MUSCLE MASS; LOWER-EXTREMITY FUNCTION; PHYSICAL PERFORMANCE; BODY-COMPOSITION; OLDER-ADULTS; GRIP STRENGTH; GAIT SPEED; ENERGY; POWER;

D O I：

10.1007/s00223-013-9757-z

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

This review provides a framework for the development of an operational definition of sarcopenia and of the potential end points that might be adopted in clinical trials among older adults. While the clinical relevance of sarcopenia is widely recognized, there is currently no universally accepted definition of the disorder. The development of interventions to alter the natural history of sarcopenia also requires consensus on the most appropriate end points for determining outcomes of clinical importance which might be utilized in intervention studies. We review current approaches to the definition of sarcopenia and the methods used for the assessment of various aspects of physical function in older people. The potential end points of muscle mass, muscle strength, muscle power, and muscle fatigue, as well as the relationships between them, are explored with reference to the availability and practicality of the available methods for measuring these end points in clinical trials. Based on current evidence, none of the four potential outcomes in question is sufficiently comprehensive to recommend as a uniform single outcome in randomized clinical trials. We propose that sarcopenia may be optimally defined (for the purposes of clinical trial inclusion criteria as well as epidemiological studies) using a combination of measures of muscle mass and physical performance. The choice of outcome measures for clinical trials in sarcopenia is more difficult; co-primary outcomes, tailored to the specific intervention in question, may be the best way forward in this difficult but clinically important area.

引用

页码：201 / 210

页数：10

共 58 条

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Evidence-Based Criteria for Sarcopenia with Clinically Important Weakness [J].