Toxicity of ad lib. overfeeding: effects on cardiac tissue

被引：22

作者：

Faine, LA

Diniz, YS

Almeida, JA

Novelli, ELB ^{[1
]}

Ribas, BO

机构：

[1] Univ Estadual Paulista, Inst Biociencias, Dept Chem & Biochem, Sao Paulo, Brazil

[2] Univ Estadual Paulista, Fac Med, Sao Paulo, Brazil

[3] Inst Salud Carlos III, Natl Ctr Environm Hlth, Dept Toxicol, Madrid, Spain

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2002年 / 40卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

rat; reactive oxygen species; overfeeding; dietary restriction; heart;

D O I：

10.1016/S0278-6915(02)00004-2

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of the present study was to determine the effects of ad lib, overfeeding and of dietary restriction (DR) on oxidative stress in cardiac tissue. Lipoperoxide concentrations ere decreased and antioxidant enzymes ere increased in moderate-DR-fed rats. Severe-DR induced increased lipoperoxide concentrations. Overfeeding increased lipoperoxide levels in cardiac tissue. Total superoxide dismutase (SOD) and Cu-Zn superoxide dismutase (Cu-Zn SOD) activities were decreased in cardiac tissue at 35 days of overfeeding. As no changes in glutathione peroxidase (GSH-Px) ere observed in overfed rats, awhile SOD and Cu-Zn SOD activities were decreased in these animals. it is assumed that superoxide anion is an important intermediate in the toxicity of ad lib, overfeeding. Overfeeding induced alterations in markers of oxidative stress in cardiac tissue. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：663 / 668

页数：6

共 43 条

[11] Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward? [J].