Pathogenesis of porcine reproductive and respiratory syndrome virus

被引：153

作者：

Chand, Ranjni J. ^{[1
]}

Trible, Benjamin R. ^{[1
]}

Rowland, Raymond R. R. ^{[1
]}

机构：

[1] Kansas State Univ, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA

来源：

CURRENT OPINION IN VIROLOGY | 2012年 / 2卷 / 03期

关键词：

INTERFERON-BETA PRODUCTION; CYSTEINE PROTEASE DOMAIN; NEUTRALIZATION EPITOPE; NORTH-AMERICAN; GP5; EVOLUTION; INFECTION; STRAIN; IDENTIFICATION; ARTERIVIRUS;

D O I：

10.1016/j.coviro.2012.02.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.

引用

页码：256 / 263

页数：8

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