Pathogenesis of porcine reproductive and respiratory syndrome virus

被引：153

作者：

Chand, Ranjni J. ^{[1
]}

Trible, Benjamin R. ^{[1
]}

Rowland, Raymond R. R. ^{[1
]}

机构：

[1] Kansas State Univ, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA

来源：

CURRENT OPINION IN VIROLOGY | 2012年 / 2卷 / 03期

关键词：

INTERFERON-BETA PRODUCTION; CYSTEINE PROTEASE DOMAIN; NEUTRALIZATION EPITOPE; NORTH-AMERICAN; GP5; EVOLUTION; INFECTION; STRAIN; IDENTIFICATION; ARTERIVIRUS;

D O I：

10.1016/j.coviro.2012.02.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.

引用

页码：256 / 263

页数：8

共 49 条

[21] Porcine Reproductive and Respiratory Syndrome Virus isolates differ in their susceptibility to neutralization [J].

Javier Martinez-Lobo, F. ;

Diez-Fuertes, Francisco ;

Simarro, Isabel ;

Castro, Jose M. ;

Prieto, Cinta .

VACCINE, 2011, 29 (40) :6928-6940

[22] Rates of molecular evolution in RNA viruses: A quantitative phylogenetic analysis [J].

Jenkins, GM ;

Rambaut, A ;

Pybus, OG ;

Holmes, EC .

JOURNAL OF MOLECULAR EVOLUTION, 2002, 54 (02) :156-165

[23] Influence of porcine reproductive and respiratory syndrome virus GP5 glycoprotein N-linked glycans on immune responses in mice [J].

Jiang, Wenming ;

Jiang, Ping ;

Wang, Xinglong ;

Li, Yufeng ;

Wang, Xianwei ;

Du, Yijun .

VIRUS GENES, 2007, 35 (03) :663-671

[24] Novel structural protein in porcine reproductive and respiratory syndrome virus encoded by an alternative ORF5 present in all arteriviruses [J].

Johnson, Craig R. ;

Griggs, Theodor F. ;

Gnanandarajah, Josephine ;

Murtaugh, Michael P. .

JOURNAL OF GENERAL VIROLOGY, 2011, 92 :1107-1116

[25] Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells [J].

Kim, Oekyung ;

Sun, Yan ;

Lai, Frances W. ;

Song, Cheng ;

Yoo, Dongwan .

VIROLOGY, 2010, 402 (02) :315-326

[26] Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene [J].

Li, Bin ;

Xiao, Shaobo ;

Wang, Yanwei ;

Xu, Shanshan ;

Jiang, Yunbo ;

Chen, Huanchun ;

Fang, Liurong .

VACCINE, 2009, 27 (13) :1957-1963

[27] The cysteine protease domain of porcine reproductive and respiratory syndrome virus non-structural protein 2 antagonizes interferon regulatory factor 3 activation [J].

Li, Hongxia ;

Zheng, Zhenhua ;

Zhou, Peng ;

Zhang, Bing ;

Shi, Zhengli ;

Hu, Qinxue ;

Wang, Hanzhong .

JOURNAL OF GENERAL VIROLOGY, 2010, 91 :2947-2958

[28] Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS host genetics consortium [J].

Joan K Lunney ;

Juan Pedro Steibel ;

James M Reecy ;

Eric Fritz ;

Max F Rothschild ;

Maureen Kerrigan ;

B Trible ;

Raymond RR Rowland .

BMC Proceedings, 5 (Suppl 4)

[29] Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-β production by interfering with the RIG-I signaling pathway [J].

Luo, Rui ;

Xiao, Shaobo ;

Jiang, Yunbo ;

Jin, Hui ;

Wang, Dang ;

Liu, Manli ;

Chen, Huanchun ;

Fang, Liurong .

MOLECULAR IMMUNOLOGY, 2008, 45 (10) :2839-2846

[30] Porcine reproductive and respiratory syndrome virus comparison: Divergent evolution on two continents [J].

Nelsen, CJ ;

Murtaugh, MP ;

Faaberg, KS .

JOURNAL OF VIROLOGY, 1999, 73 (01) :270-280

← 1 2 3 4 5 →