Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver

被引:110
作者
Exley, MA
He, Q
Cheng, O
Wang, RJ
Cheney, CP
Balk, SP
Koziel, MJ
机构
[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Canc Biol Program, Sch Med, Boston, MA 02215 USA
[2] Harvard Univ, Beth Israel Deaconess Med Ctr, Div Infect Dis, Sch Med, Boston, MA 02215 USA
[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Sch Med,Div Gastroenterol, Boston, MA 02215 USA
关键词
D O I
10.4049/jimmunol.168.4.1519
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Murine intrahepatic lymphocytes (IHL) are dominated by invariant TCR alpha-chain expressing CD1d-reactive NKT cells, which can cause model hepatitis. Invariant NKT (CD56(+/-)CD161(+)) and recently identified noninvariant CD1d-reactive T cells rapidly produce large amounts of IL-4 and/or IFN-gamma and can regulate Th1/Th2 responses. Human liver contains large numbers of CD56(+) NKT cells but few invariant NKT. Compared with matched peripheral blood T cell lines, primary IHL lines from patients with chronic hepatitis C had high levels of CD161 and CD1d reactivity, but the invariant TCR was rare. CD1d-reactive IHL were strikingly Th1 biased. 1311, also demonstrated CD1d-specific cytotoxic activity. Hepatocytes and other liver cells express CD1d. These results identify a novel population of human T cells that could contribute to destructive as well as protective immune responses in the liver. CD1d-reactive T cells may have distinct roles in different tissues.
引用
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页码:1519 / 1523
页数:5
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